| Description |
1 online resource |
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text txt rdacontent |
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computer c rdamedia |
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online resource cr rdacarrier |
| Series |
Studies in Natural Products Chemistry ; 44
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| Bibliography |
Includes bibliographical references and index. |
| Note |
CIP data; resource not viewed. |
| Summary |
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. |
| Contents |
Cover; Title Page; Copyright Page; Contents; Contributors; Preface; Chapter 1 -- Terpenoids and Sterols from Mushrooms; Introduction; Sesquiterpenoids; Lactarane-Type Sesquiterpenoids; Marasmane-Type Sesquiterpenoids; Nardosinane-Type and Aristolane-Type Sesquiterpenoids; Protoilludane-Type Sesquiterpenoids; Russulane-Type Norsesquiterpenoids; Triterpenoids; Lanostane-Type Triterpenoids; Cucurbitane-Type Triterpenoids; Sterols; Sterols Bearing 5a,6a-Epoxy Group; Sterols Bearing 5a,9a-Epidioxy and 5b,9b-Dihydroxy Groups; Sterols Bearing Enone, Diene, and Ketone Moieties |
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Sterols Bearing 3b,5a,6b,7a-Tetrahydroxy, 3b,5a,6a,9a-Tetrahydroxy, and 3b,5a,6b,9a-Tetrahydroxy Groups23-Methylergostane-Type Sterols; Sterols Bearing 1,2,3,4,5,10,19-Heptanor Structure; Meroterpenoids; Conclusions; Abbreviations; References; Chapter 2 -- From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs); Introduction; Neglected Tropical Diseases; Tuberculosis; Leishmaniasis; Malaria; Chagas Disease (American Trypanosomiasis); Human African Trypanosomiasis (Sleeping Sickness); Dengue; Lymphatic Filariasis (Elephantiasis); Helminthiasis |
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Leprosy (Hansen Disease)Trachoma; Buruli Ulcer; Schistosomiasis; Conclusions; Abbreviations; References; Chapter 3 -- Febrifugine and Its Analogs: Studies for Their Antimalarial and Other Therapeutic Properties; Introduction; Discovery; Structure Elucidation; Chemical and physical Properties of Febrifugine; Synthesis of Febrifugine; Pharmacology of Febrifugine; Antimalarial Activity of Febrifugine; Anticoccidial Activity; Toxicity; Febrifugine Analogs; Halofuginone; Antimalarial Properties; Coccidiosis; Autoimmune Diseases; Other Diseases; Polypharmacy; Abbreviations; Concluding Remarks |
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AcknowledgmentsReferences; Chapter 4 -- Macrocyclic N-Methylated Cyclic Peptides and Depsipeptides; Introduction; Aureobasidins; Introduction; Isolation; Classification of Abs; Structural Determination; Biological Activity; Synthesis; Total Synthesis of Abs; Semisynthesis of Abs; Cyclosporins; Introduction; Isolation; Classification of Cs; Structural Determination; Biological Activity; Synthesis; Synthesis of Cyclosporins; Synthesis of Unusual Amino Acid MeBmt; Dolastatin; Introduction; Isolation; Classification of Cyclic Peptides; Cyclopeptides; Cyclodepsipeptides; Structure Determination |
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Biological ActivitySynthesis; Didemnins; Introduction; Isolation; Classification of Didemnins; Structural Determination; Biological Activity; Synthesis; Total Syntheses of Didemnin, the Natural Products; Syntheses of Didemnin Analogs; Miscellaneous Cyclopeptides and Cyclodepsipeptide; Introduction; Omphalotins; Petriellin; Clavariopsins; Somamides; Salinamides; Abbreviations; Conclusion; References; Chapter 5 -- Anticancer Drugs and Potential Anticancer Leads Inspired by Natural Products; Introduction; Tubulin/Microtubule-Targeted Anticancer Agents |
| Subject |
Bioorganic chemistry.
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Bioactive compounds.
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Natural products.
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Chimie bio-organique.
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Composés bioactifs.
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Produits naturels.
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SCIENCE -- Life Sciences -- Biochemistry.
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Bioactive compounds
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Bioorganic chemistry
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Natural products
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| Added Author |
Rahman, Atta-ur-, 1942- editor.
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| Other Form: |
Print version: Studies in natural products chemistry. Volume 44 9780444634603 (OCoLC)913791672 |
| ISBN |
9780444634702 (electronic bk.) |
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0444634703 (electronic bk.) |
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9780444634603 (hbk.) |
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0444634606 (hbk.) |
| Standard No. |
AU@ 000062547856 |
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CHBIS 010547553 |
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CHVBK 341780383 |
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DEBBG BV043216203 |
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DEBSZ 427902649 |
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DEBSZ 482373067 |
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GBVCP 819926094 |
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NZ1 15919184 |
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NZ1 16245956 |
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UKMGB 016941231 |
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